InVivoMAb Anti-Clostridioides difficile Toxin A/tcdA Antibody (PA50) (JN085010)

Name: InVivoMAb Anti-Clostridioides difficile Toxin A/tcdA Antibody (PA50)
Brand: abinScience
SKU: JN085010
Price: 370 USD
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100ug
1mg

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Número de catálogo	JN085010
Descripción	InVivoMAb Anti-Clostridioides difficile Toxin A/tcdA Antibody (PA50) [PA50] (JN085010) is a human monoclonal antibody detecting toxA in Neutralization, SPR.
Reactividad de especies	Clostridioides difficile
Aplicaciones	Neutralization, SPR
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	PA50
Objetivo	toxA, TcdA, Toxin A, Clostridioides difficile (Peptoclostridium difficile), Clostridium difficile Toxin
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Productos asociados	pH 7.4 Dilution Buffer
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P16154
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Toxin A (tcdA) is a ~308 kDa protein. Precursor of a cytotoxin that targets and disrupts the colonic epithelium, inducing the host inflammatory and innate immune responses and resulting in diarrhea and pseudomembranous colitis. TcdA and TcdB constitute the main toxins that mediate the pathology of C.difficile infection, an opportunistic pathogen that colonizes the colon when the normal gut microbiome is disrupted. Compared to TcdB, TcdA is less virulent and less important for inducing the host inflammatory and innate immune responses. This form constitutes the precursor of the toxin: it enters into host cells and mediates autoprocessing to release the active toxin (Glucosyltransferase TcdA) into the host cytosol. Targets colonic epithelia by binding to some receptor, and enters host cells via clathrin-mediated endocytosis. 1. Kuehne, SA. et al. (2010) Nature 467, 711-3. PMID: 20844489 2. Lyras, D. et al. (2009) Nature 458, 1176-9. PMID: 19252482 3. Greco, A. et al. (2006) Nature structural & molecular biology 13, 460-1. PMID: 16622409 4. Tucker, KD. et al. (1991) Infection and immunity 59, 73-8. PMID: 1670930 5. Tao, L. et al. (2019) Nature microbiology 4, 1760-1769. PMID: 31160825 6. Tao, L. et al. (2016) Nature 538, 350-355. PMID: 27680706 7. Reineke, J. et al. (2007) Nature 446, 415-9. PMID: 17334356 8. Pruitt, RN. et al. (2009) The Journal of biological chemistry 284, 21934-21940. PMID: 19553670
Nota	For research use only. Not suitable for clinical or therapeutic use.