InVivoMAb Anti-Clostridioides difficile Toxin A/tcdA Antibody (PA50) (JN085010)

Name: InVivoMAb Anti-Clostridioides difficile Toxin A/tcdA Antibody (PA50)
Brand: abinScience
SKU: JN085010
Price: 370 USD
Availability: InStock

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100ug
1mg

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Каталожный номер	JN085010
Описание	InVivoMAb Anti-Clostridioides difficile Toxin A/tcdA Antibody (PA50) [PA50] (JN085010) is a human monoclonal antibody detecting toxA in Neutralization, SPR.
Реактивность видов	Clostridioides difficile
Применения	Neutralization, SPR
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1, kappa
ID клона	PA50
Цель	toxA, TcdA, Toxin A, Clostridioides difficile (Peptoclostridium difficile), Clostridium difficile Toxin
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Связанные продукты	pH 7.4 Dilution Buffer
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P16154
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Toxin A (tcdA) is a ~308 kDa protein. Precursor of a cytotoxin that targets and disrupts the colonic epithelium, inducing the host inflammatory and innate immune responses and resulting in diarrhea and pseudomembranous colitis. TcdA and TcdB constitute the main toxins that mediate the pathology of C.difficile infection, an opportunistic pathogen that colonizes the colon when the normal gut microbiome is disrupted. Compared to TcdB, TcdA is less virulent and less important for inducing the host inflammatory and innate immune responses. This form constitutes the precursor of the toxin: it enters into host cells and mediates autoprocessing to release the active toxin (Glucosyltransferase TcdA) into the host cytosol. Targets colonic epithelia by binding to some receptor, and enters host cells via clathrin-mediated endocytosis. 1. Kuehne, SA. et al. (2010) Nature 467, 711-3. PMID: 20844489 2. Lyras, D. et al. (2009) Nature 458, 1176-9. PMID: 19252482 3. Greco, A. et al. (2006) Nature structural & molecular biology 13, 460-1. PMID: 16622409 4. Tucker, KD. et al. (1991) Infection and immunity 59, 73-8. PMID: 1670930 5. Tao, L. et al. (2019) Nature microbiology 4, 1760-1769. PMID: 31160825 6. Tao, L. et al. (2016) Nature 538, 350-355. PMID: 27680706 7. Reineke, J. et al. (2007) Nature 446, 415-9. PMID: 17334356 8. Pruitt, RN. et al. (2009) The Journal of biological chemistry 284, 21934-21940. PMID: 19553670
Примечание	For research use only. Not suitable for clinical or therapeutic use.