InVivoMAb Anti-Clostridium botulinum botA/BOTOX Antibody (BNTA-4.1) (JN888020)

Name: InVivoMAb Anti-Clostridium botulinum botA/BOTOX Antibody (BNTA-4.1)
Brand: abinScience
SKU: JN888020
Price: 370 USD
Availability: InStock

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100ug
1mg

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Каталожный номер	JN888020
Описание	InVivoMAb Anti-Clostridium botulinum botA/BoNT Antibody (BNTA-4.1) [BNTA-4.1] (JN888020) is a human monoclonal antibody detecting Botulinum neurotoxin type A in ELISA, Neutralization.
Реактивность видов	Clostridium botulinum
Применения	ELISA, Neutralization
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1
ID клона	BNTA-4.1
Цель	Botulinum neurotoxin type A, BoNT/A, Bontoxilysin-A, BOTOX, Botulinum neurotoxin type A1, Botulinum neurotoxin A light chain, LC, 3.4.24.69, Botulinum neurotoxin A heavy chain, HC, botA, atx, bonT
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Связанные продукты	pH 7.4 Dilution Buffer
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P0DPI0
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Botulinum neurotoxin type A (botA/BoNT) is a ~149 kDa protein. Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin A which has 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins of synaptic vesicles. Receptor proteins are exposed on host presynaptic cell membrane during neurotransmitter release, when the toxin heavy chain (HC) binds to them. Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway. When the pH of the toxin-containing endosome drops a structural rearrangement occurs so that the N-terminus of the HC forms pores that allows the light chain (LC) to translocate into the cytosol. 1. BURGEN, AS. et al. (1949) The Journal of physiology 109, 10-24. PMID: 15394302 2. Zhou, L. et al. (1995) Biochemistry 34, 15175-81. PMID: 7578132 3. Fischer, A. et al. (2007) The Journal of biological chemistry 282, 29604-11. PMID: 17666397 4. Fischer, A. et al. (2008) PLoS pathogens 4, e1000245. PMID: 19096517 5. Yowler, BC. et al. (2002) The Journal of biological chemistry 277, 32815-9. PMID: 12089155 6. Dong, M. et al. (2006) Science (New York, N.Y.) 312, 592-6. PMID: 16543415 7. Mahrhold, S. et al. (2006) FEBS letters 580, 2011-4. PMID: 16545378 8. Dong, M. et al. (2008) Molecular biology of the cell 19, 5226-37. PMID: 18815274
Примечание	For research use only. Not suitable for clinical or therapeutic use.