InVivoMAb Anti-Human Proadrenomedullin/Pro-ADM Antibody (Iv0159) (HW442010)

Name: InVivoMAb Anti-Human Proadrenomedullin/Pro-ADM Antibody (Iv0159)
Brand: abinScience
SKU: HW442010
Price: 370 USD
Availability: InStock

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100ug
1mg

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Aperçu

Numéro de catalogue	HW442010
Description	InVivoMAb Anti-Human ADM Antibody (Iv0159) [Iv0159] (HW442010) is a human monoclonal antibody detecting ProAM N-terminal 20 peptide in ELISA, FCM, Neutralization. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Reactivité des espèces	Human
Applications	ELISA, FCM, Neutralization
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1, kappa
ID de clone	Iv0159
Cible	ProAM N-terminal 20 peptide, PAMP, Pro-adrenomedullin, AM, ProAM-N20, ADM
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>95% as determined by SDS-PAGE.
Produits associés	pH 7.4 Dilution Buffer
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P35318
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Pro-adrenomedullin (ADM) is a ~20 kDa protein. Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. 1. Kitamura, K. et al. (1993) Biochemical and biophysical research communications 192, 553-60. PMID: 8387282 2. McLatchie, LM. et al. (1998) Nature 393, 333-9. PMID: 9620797
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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Flow Cytometry

Flow-cytometry using anti-human adrenomedullin antibody.MDA-MB-435 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human adrenomedullin antibody monoclonal antibody (Catalog # HW442010 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-human antibody (Catalog # HF690414) and cells analysed on a NovoCyte Flow Cytometer.
SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Human ADM Antibody (Iv0159).