InVivoMAb Anti-Human Proadrenomedullin/Pro-ADM Antibody (Iv0159) (HW442010)

Name: InVivoMAb Anti-Human Proadrenomedullin/Pro-ADM Antibody (Iv0159)
Brand: abinScience
SKU: HW442010
Price: 370 USD
Availability: InStock

データシート製品共有情報コピー

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100ug
1mg

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HW442010
説明	InVivoMAb Anti-Human ADM Antibody (Iv0159) [Iv0159] (HW442010) is a human monoclonal antibody detecting ProAM N-terminal 20 peptide in ELISA, FCM, Neutralization. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
種反応性	Human
アプリケーション	ELISA, FCM, Neutralization
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1, kappa
クローンID	Iv0159
ターゲット	ProAM N-terminal 20 peptide, PAMP, Pro-adrenomedullin, AM, ProAM-N20, ADM
エンドトキシンレベル	Please contact with the lab for this information.
純度	>95% as determined by SDS-PAGE.
関連製品	pH 7.4 Dilution Buffer
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P35318
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Pro-adrenomedullin (ADM) is a ~20 kDa protein. Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. 1. Kitamura, K. et al. (1993) Biochemical and biophysical research communications 192, 553-60. PMID: 8387282 2. McLatchie, LM. et al. (1998) Nature 393, 333-9. PMID: 9620797
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

イメージ

Flow Cytometry

Flow-cytometry using anti-human adrenomedullin antibody.MDA-MB-435 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human adrenomedullin antibody monoclonal antibody (Catalog # HW442010 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-human antibody (Catalog # HF690414) and cells analysed on a NovoCyte Flow Cytometer.
SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Human ADM Antibody (Iv0159).