InVivoMAb Anti-Human Dkk-1 Antibody (DKN-01) (HF914010)

Name: InVivoMAb Anti-Human Dkk-1 Antibody (DKN-01)
Brand: abinScience
SKU: HF914010
Price: 370 USD
Availability: InStock

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100ug
1mg

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HF914010
説明	InVivoMAb Anti-Human DKK1 Antibody (DKN-01) [DKN-01] (HF914010) is a mouse monoclonal antibody detecting Dickkopf-1 in ELISA, Neutralization. Suitable for Human.
種反応性	Human
アプリケーション	ELISA, Neutralization
宿主種	Mouse
クローン性	Monoclonal
アイソタイプ	IgG2a, kappa
クローンID	DKN-01
ターゲット	Dickkopf-1, SK, hDkk-1, Dkk-1, Dickkopf-related protein 1, DKK1
エンドトキシンレベル	Please contact with the lab for this information.
純度	>95% as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	O94907
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Dickkopf-related protein 1 (DKK1) is a ~28 kDa protein. Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. 1. Ahn, VE. et al. (2011) Developmental cell 21, 862-73. PMID: 22000856 2. Niehrs, C. (2006) Oncogene 25, 7469-81. PMID: 17143291
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)