InVivoMAb Anti-Human Gremlin Antibody (Iv0131) (HT246010)

Name: InVivoMAb Anti-Human Gremlin Antibody (Iv0131)
Brand: abinScience
SKU: HT246010
Price: 370 USD
Availability: InStock

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Спецификация:

100ug
1mg

Количество:

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Даташит
SDS

Обзор

Каталожный номер	HT246010
Описание	InVivoMAb Anti-Human GREM1/DAND2 Antibody (Iv0131) [Iv0131] (HT246010) is a human monoclonal antibody detecting Cysteine knot superfamily 1 in ELISA, FCM, Neutralization. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Реактивность видов	Human
Применения	ELISA, FCM, Neutralization
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG4, kappa
ID клона	Iv0131
Цель	Cysteine knot superfamily 1, BMP antagonist 1, CKTSF1B1, Down-regulated in Mos-transformed cells protein, Increased in high glucose protein 2, IHG-2, DRM, GREM1, Gremlin-1, Cell proliferation-inducing gene 2 protein, DAN domain family member 2, DAND2
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Связанные продукты	pH 7.4 Dilution Buffer
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	O60565
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Gremlin-1 (GREM1/DAND2) is a ~20 kDa protein. Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed. 1. Kišonaitė, M. et al. (2016) The Biochemical journal 473, 1593-604. PMID: 27036124
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)

Изображения

Flow Cytometry

Flow-cytometry using anti-human GREM1 antibody.GREM1 Transfected CHO cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human GREM1 antibody monoclonal antibody (Catalog # HT246010 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-human antibody (Catalog # HF690414) and cells analysed on a NovoCyte Flow Cytometer.
SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Human GREM1/DAND2 Antibody (Iv0131).