InVivoMAb Anti-Human TSHR Antibody (K1-18) (HB852010)

Name: InVivoMAb Anti-Human TSHR Antibody (K1-18)
Brand: abinScience
SKU: HB852010
Price: 370 USD
Availability: InStock

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100ug
1mg

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Número de catálogo	HB852010
Descripción	InVivoMAb Anti-Human TSHR/LGR3 Antibody (K1-18) [K1-18] (HB852010) is a mouse monoclonal antibody detecting Thyroid-stimulating hormone receptor in Agonist, ELISA, IHC. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications.
Reactividad de especies	Human
Aplicaciones	Agonist, ELISA, IHC
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG2a, kappa
ID de clon	K1-18
Objetivo	Thyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Productos asociados	pH 7.4 Dilution Buffer
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P16473
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Thyrotropin receptor (TSHR/LGR3) is a ~86 kDa protein. Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS). 1. Costagliola, S. et al. (2002) The EMBO journal 21, 504-13. PMID: 11847099 2. Nakabayashi, K. et al. (2002) The Journal of clinical investigation 109, 1445-52. PMID: 12045258 3. Faust, B. et al. (2022) Nature 609, 846-853. PMID: 35940205 4. Duan, J. et al. (2022) Nature 609, 854-859. PMID: 35940204 5. Morgan, SJ. et al. (2016) Thyroid : official journal of the American Thyroid Association 26, 1794-1803. PMID: 27638195
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)