InVivoMAb Anti-Mouse ANGPTL4 Antibody (4A8) (HV344020)

Name: InVivoMAb Anti-Mouse ANGPTL4 Antibody (4A8)
Brand: abinScience
SKU: HV344020
Price: 370 USD
Availability: InStock

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100ug
1mg

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Numéro de catalogue	HV344020
Description	InVivoMAb Anti-Mouse ANGPTL4 Antibody (4A8) [4A8] (HV344020) is a mouse monoclonal antibody detecting Angiopoietin-related protein 4 in Neutralization. Suitable for Mouse.
Reactivité des espèces	Mouse
Applications	Neutralization
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	4A8
Cible	Angiopoietin-related protein 4, 425O18-1, Angiopoietin-like protein 4, Fasting-induced adipose factor, Hepatic fibrinogen/angiopoietin-related protein, HFARP, Secreted protein Bk89, ANGPTL4 N-terminal chain, ANGPTL4 C-terminal chain, Angptl4, Farp, Fiaf, Ng27
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>95% as determined by SDS-PAGE.
Produits associés	pH 7.4 Dilution Buffer
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q9Z1P8
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Angiopoietin-related protein 4 (ANGPTL4) is a ~45 kDa protein. Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis (Probable). 1. Xu, A. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 6086-91. PMID: 15837923 2. Desai, U. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 11766-71. PMID: 17609370 3. Gusarova, V. et al. (2018) Nature communications 9, 2252. PMID: 29899519 4. Ito, Y. et al. (2003) Cancer research 63, 6651-7. PMID: 14583458 5. Galaup, A. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 18721-6. PMID: 17130448 6. Perdiguero, EG. et al. (2011) The Journal of biological chemistry 286, 36841-51. PMID: 21832056
Note	For research use only. Not suitable for clinical or therapeutic use.