InVivoMAb Anti-Mouse IL-17A Antibody (17F3) (MS856020)

Name: InVivoMAb Anti-Mouse IL-17A Antibody (17F3)
Brand: abinScience
SKU: MS856020
Price: 370 USD
Availability: InStock

Fiche technique Partager le produit Copier les informations

Prix(USD) :

Spécification :

100ug
1mg

Nombre :

Contactez-nous

Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

MS856020

Description

InVivoMAb Anti-Mouse IL17A Antibody (17F3) [17F3] (MS856020) is a mouse monoclonal antibody detecting CTLA-8 in ELISA, Neutralization. Suitable for Mouse.

Reactivité des espèces

Mouse

Applications

ELISA, Neutralization

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG1, kappa

ID de clone

17F3

Cible

CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, IL17, IL17A, Interleukin-17A

Niveau d'endotoxines

< 1 EU/mg

Pureté

>95% as determined by SDS-PAGE.

Produits associés

pH 7.4 Dilution Buffer

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q62386

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Interleukin-17A (IL17A) is a ~17 kDa protein. Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. IL17A is the therapeutic target of secukinumab (Cosentyx).

1. Liang, SC. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 7791-9. PMID: 18025225

2. Ishigame, H. et al. (2009) Immunity 30, 108-19. PMID: 19144317

3. Lee, JS. et al. (2015) Immunity 43, 727-38. PMID: 26431948

4. Park, H. et al. (2005) Nature immunology 6, 1133-41. PMID: 16200068

5. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 17911633

6. Chen, K. et al. (2016) Cell host & microbe 20, 596-605. PMID: 27923703

Note

For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Mouse IL17A Antibody (17F3)

Reférences

Fiche technique

InVivoMAb Anti-Mouse IL-17A Antibody (17F3).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai