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| カタログ番号 | MY328020 | ||||
|---|---|---|---|---|---|
| 説明 |
InVivoMAb Anti-Mouse IL6 (MP5-20F3) [MP5-20F3] (MY328020) is a rat monoclonal antibody detecting Interleukin-6 in ELISA, FACS, Functional assay, Research in vivo. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||
| アプリケーション | ELISA, FCM, Functional assay, Research in vivo | ||||
| 宿主種 | Rat | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG1, kappa | ||||
| クローンID | MP5-20F3 | ||||
| ターゲット | B-cell stimulatory factor 2, BSF-2, CDF, CTL differentiation factor, Hybridoma growth factor, IFN-beta-2, IFNB2, IL-6, IL6, Interferon beta-2, Interleukin-6 | ||||
| エンドトキシンレベル | < 1 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P08505 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Interleukin-6 (IL6) is a ~23 kDa protein. Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable). IL6 is the therapeutic target of tocilizumab (Actemra). | ||||
| 注意事項 | For research use only. | ||||
| Isotype Control | Rat IgG1, kappa Recombinant Isotype Control Antibody (RTK2071) (RV080407) |
SDS-PAGE for InVivoMAb Anti-Mouse IL-6 Antibody (MP5-20F3)
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