InVivoMAb Anti-SARS-CoV-2 RBD (JN.1 variant) Neutralizing Antibody (Iv0221) (VK565110)

Name: InVivoMAb Anti-SARS-CoV-2 RBD (JN.1 variant) Neutralizing Antibody (Iv0221)
Brand: abinScience
SKU: VK565110
Price: 370 USD
Availability: InStock

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100ug
1mg

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	VK565110
説明	InVivoMAb Anti-SARS-CoV-2 RBD (JN.1) Neutralizing Antibody (Iv0221) [Iv0221] (VK565110) is a human monoclonal antibody detecting Spike glycoprotein in ELISA, Neutralization.
種反応性	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
アプリケーション	ELISA, Neutralization
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1, kappa
クローンID	Iv0221
ターゲット	Spike glycoprotein, Spike, S glycoprotein, RBD
エンドトキシンレベル	< 1 EU/mg
純度	>95% as determined by SDS-PAGE.
関連製品	pH 7.4 Dilution Buffer
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P0DTC2
形態	Liquid
保存バッファー	0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Spike glycoprotein (RBD (Omicron/JN.1)) is a ~141 kDa protein. Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2. When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane. When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis using host TFRC and GRM2 and leading to fusion of the virion membrane with the host endosomal membrane. Alternatively, may use NRP1/NRP2 and integrin as entry receptors. 1. Hoffmann, M. et al. (2020) Cell 181, 271-280.e8. PMID: 32142651 2. Walls, AC. et al. (2020) Cell 181, 281-292.e6. PMID: 32155444 3. Cao, W. et al. (2021) Biophysical journal 120, 1011-1019. PMID: 33607086 4. Takeda, M. (2022) Microbiology and immunology 66, 15-23. PMID: 34561887 5. Wrapp, D. et al. (2020) Science (New York, N.Y.) 367, 1260-1263. PMID: 32075877 6. Ou, X. et al. (2020) Nature communications 11, 1620. PMID: 32221306 7. Wang, J. et al. (2021) Cell discovery 7, 119. PMID: 34903715 8. Wang, X. et al. (2023) Journal of virology 97, e0161122. PMID: 36779763 9. Daly, JL. et al. (2020) Science (New York, N.Y.) 370, 861-865. PMID: 33082294 10. Cantuti-Castelvetri, L. et al. (2020) Science (New York, N.Y.) 370, 856-860. PMID: 33082293
注意事項	For research use only. Not suitable for clinical or therapeutic use.

イメージ

SDS-PAGE

SDS-PAGE for InVivoMAb Anti-SARS-CoV-2 RBD (JN.1) Neutralizing Antibody (Iv0221).
Bioactivity

Detects SARS-CoV-2 RBD(JN.1) in indirect ELISAs.
Bioactivity

Detects Recombinant SARS-CoV-2 RBD (JN.1) Protein, C-His (Cat No.: VK565421) in indirect ELISA.