InVivoMAb Anti-SARS-CoV-2 S2/Spike protein S2' Antibody (D31) (VK749070)

Name: InVivoMAb Anti-SARS-CoV-2 S2/Spike protein S2' Antibody (D31)
Brand: abinScience
SKU: VK749070
Price: 370 USD
Availability: InStock

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100ug
1mg

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Каталожный номер	VK749070
Описание	InVivoMAb Anti-SARS-CoV-2 S2/Spike protein S2' Antibody (D31) [D31] (VK749070) is a mouse monoclonal antibody detecting Spike glycoprotein in Blocking, ELISA.
Реактивность видов	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Применения	Blocking, ELISA
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG2a, kappa
ID клона	D31
Цель	Spike glycoprotein, S glycoprotein, Spike protein S2', S, 2, SARS-CoV-2 (2019-nCoV)
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Связанные продукты	pH 7.4 Dilution Buffer
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P0DTC2
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Spike glycoprotein (S2/Spike protein S2') is a ~141 kDa protein. Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2. When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane. When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis using host TFRC and GRM2 and leading to fusion of the virion membrane with the host endosomal membrane. Alternatively, may use NRP1/NRP2 and integrin as entry receptors. 1. Hoffmann, M. et al. (2020) Cell 181, 271-280.e8. PMID: 32142651 2. Walls, AC. et al. (2020) Cell 181, 281-292.e6. PMID: 32155444 3. Cao, W. et al. (2021) Biophysical journal 120, 1011-1019. PMID: 33607086 4. Takeda, M. (2022) Microbiology and immunology 66, 15-23. PMID: 34561887 5. Wrapp, D. et al. (2020) Science (New York, N.Y.) 367, 1260-1263. PMID: 32075877 6. Ou, X. et al. (2020) Nature communications 11, 1620. PMID: 32221306 7. Wang, J. et al. (2021) Cell discovery 7, 119. PMID: 34903715 8. Wang, X. et al. (2023) Journal of virology 97, e0161122. PMID: 36779763 9. Daly, JL. et al. (2020) Science (New York, N.Y.) 370, 861-865. PMID: 33082294 10. Cantuti-Castelvetri, L. et al. (2020) Science (New York, N.Y.) 370, 856-860. PMID: 33082293
Примечание	For research use only. Not suitable for clinical or therapeutic use.