InVivoMAb Anti-SEBOV/ZEBOV Glycoprotein Antibody (Iv0198) (VK623050)

Name: InVivoMAb Anti-SEBOV/ZEBOV Glycoprotein Antibody (Iv0198)
Brand: abinScience
SKU: VK623050
Price: 370 USD
Availability: InStock

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100ug
1mg

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Número de catálogo	VK623050
Descripción	InVivoMAb Anti-SEBOV/ZEBOV GP/Envelope glycoprotein Antibody (Iv0198) [Iv0198] (VK623050) is a human monoclonal antibody detecting Envelope glycoprotein in ELISA, FCM, Neutralization. Suitable for Ebola virus and Zaire ebolavirus. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Reactividad de especies	Sudan ebolavirus (SEBOV) (Sudan Ebola virus), Zaire ebolavirus (ZEBOV) (Zaire Ebola virus)
Aplicaciones	ELISA, FCM, Neutralization
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	Iv0198
Objetivo	Envelope glycoprotein, GP, GP1, GP1,2, GP1,2-delta, GP2, Shed GP
Nivel de endotoxinas	< 1 EU/mg
Pureza	>95% as determined by SDS-PAGE.
Productos asociados	pH 7.4 Dilution Buffer
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q05320
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Envelope glycoprotein (GP) is a ~74 kDa protein. Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, down-regulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes.
Nota	For research use only. Not suitable for clinical or therapeutic use.