InVivoMAb Anti-SEBOV/ZEBOV Glycoprotein Antibody (Iv0198) (VK623050)

Name: InVivoMAb Anti-SEBOV/ZEBOV Glycoprotein Antibody (Iv0198)
Brand: abinScience
SKU: VK623050
Price: 370 USD
Availability: InStock

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100ug
1mg

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Numéro de catalogue	VK623050
Description	InVivoMAb Anti-SEBOV/ZEBOV GP/Envelope glycoprotein Antibody (Iv0198) [Iv0198] (VK623050) is a human monoclonal antibody detecting Envelope glycoprotein in ELISA, FCM, Neutralization. Suitable for Ebola virus and Zaire ebolavirus. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Reactivité des espèces	Sudan ebolavirus (SEBOV) (Sudan Ebola virus), Zaire ebolavirus (ZEBOV) (Zaire Ebola virus)
Applications	ELISA, FCM, Neutralization
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG
ID de clone	Iv0198
Cible	Envelope glycoprotein, GP, GP1, GP1,2, GP1,2-delta, GP2, Shed GP
Niveau d'endotoxines	< 1 EU/mg
Pureté	>95% as determined by SDS-PAGE.
Produits associés	pH 7.4 Dilution Buffer
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q05320
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Envelope glycoprotein (GP) is a ~74 kDa protein. Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, down-regulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes.
Note	For research use only. Not suitable for clinical or therapeutic use.