Mouse Anti-Human BMP2 Recombinant Antibody (Iv0058) (HY576023)

Name: Mouse Anti-Human BMP2 Recombinant Antibody (Iv0058)
Brand: abinScience
SKU: HY576023
Price: 110 USD
Availability: InStock

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Precio(USD):

Especificación:

20ug
50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HY576023

Reactividad de especies

Human

Aplicaciones

ELISA, FCM, Neutralization

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a, kappa

ID de clon

Iv0058

Objetivo

BMP-2, BMP2A, Bone morphogenetic protein 2A, Bone morphogenetic protein 2, BMP2, BMP-2A

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

P12643

RRID

Mouse Anti-Human BMP2 Antibody (Iv0058) (abinScience Cat# HY576023, RRID:AB_3729371)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Reconstitución

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Bone morphogenetic protein 2 (BMP2) is a ~44 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.

1. Lavery, K. et al. (2008) The Journal of biological chemistry 283, 20948-58. PMID: 18436533

2. Tanaka, K. et al. (2014) Calcified tissue international 94, 454-64. PMID: 24362451

3. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025

4. Wozney, JM. et al. (1988) Science (New York, N.Y.) 242, 1528-34. PMID: 3201241

5. Keller, S. et al. (2004) Nature structural & molecular biology 11, 481-8. PMID: 15064755

6. Weber, D. et al. (2007) BMC structural biology 7, 6. PMID: 17295905

7. Liu, F. et al. (1995) Molecular and cellular biology 15, 3479-86. PMID: 7791754

8. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957

9. Tsukahara, S. et al. (2006) The Biochemical journal 398, 595-603. PMID: 16771708

Nota

For research use only.

Isotype Control

Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

Imágenes

SDS-PAGE

SDS-PAGE for Mouse Anti-Human BMP2 Antibody (Iv0058).
Flow CytoMetry

Flow-cytometry using PE anti-human BMP4 antibody. HepG-2 cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an PE anti-human BMP4 monoclonal antibody (Catalog: HY576023, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

Referencias

Datasheet

Mouse Anti-Human BMP2 Recombinant Antibody (Iv0058).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo