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| カタログ番号 | HY576023 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, FCM, Neutralization | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | Iv0058 | ||||
| ターゲット | BMP-2, BMP2A, Bone morphogenetic protein 2A, Bone morphogenetic protein 2, BMP2, BMP-2A | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P12643 | ||||
| RRID | Mouse Anti-Human BMP2 Antibody (Iv0058) (abinScience Cat# HY576023, RRID:AB_3729371) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. | ||||
| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Bone morphogenetic protein 2 (BMP2) is a ~44 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. 1. Lavery, K. et al. (2008) The Journal of biological chemistry 283, 20948-58. PMID: 18436533 2. Tanaka, K. et al. (2014) Calcified tissue international 94, 454-64. PMID: 24362451 3. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025 4. Wozney, JM. et al. (1988) Science (New York, N.Y.) 242, 1528-34. PMID: 3201241 5. Keller, S. et al. (2004) Nature structural & molecular biology 11, 481-8. PMID: 15064755 6. Weber, D. et al. (2007) BMC structural biology 7, 6. PMID: 17295905 7. Liu, F. et al. (1995) Molecular and cellular biology 15, 3479-86. PMID: 7791754 8. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957 9. Tsukahara, S. et al. (2006) The Biochemical journal 398, 595-603. PMID: 16771708 | ||||
| 注意事項 | For research use only. | ||||
| Isotype Control | Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023) |
SDS-PAGE for Mouse Anti-Human BMP2 Antibody (Iv0058).
Flow-cytometry using PE anti-human BMP4 antibody. HepG-2 cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an PE anti-human BMP4 monoclonal antibody (Catalog: HY576023, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
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