Human AARS2 Recombinant Protein (N-His) (HD871012)

Name: Human AARS2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD871012
Price: 211 USD
Availability: InStock

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1mg

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Número de catálogo	HD871012
Descripción	Recombinant Human AARS2 Protein, N-His (HD871012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q5JTZ9
Longitud de proteína	Gly24-Ala484
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	AARS2, AARSL, AlaRS, Alanine--tRNA ligase, mitochondrial, Alanyl-tRNA synthetase, EC:6.-.-.-, EC:6.1.1.7, KIAA1270, Protein lactyltransferase AARS2
Fondo	Alanine--tRNA ligase, mitochondrial is a ~107 kDa protein. Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as CGAS. Acts as an inhibitor of cGAS/STING signaling by catalyzing lactylation of CGAS, preventing the formation of liquid-like droplets in which CGAS is activated. 1. Götz, A. et al. (2011) American journal of human genetics 88, 635-42. PMID: 21549344 2. Li, H. et al. (2024) Nature 634, 1229-1237. PMID: 39322678
Nota	For research use only

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Datasheet

Human AARS2 Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Mass

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Volume

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g/mol

Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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