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| カタログ番号 | HD871012 |
|---|---|
| 説明 |
Recombinant Human AARS2 Protein, N-His (HD871012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q5JTZ9 |
| タンパク質長 | Gly24-Ala484 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | AARS2, AARSL, AlaRS, Alanine--tRNA ligase, mitochondrial, Alanyl-tRNA synthetase, EC:6.-.-.-, EC:6.1.1.7, KIAA1270, Protein lactyltransferase AARS2 |
| 背景 | Alanine--tRNA ligase, mitochondrial is a ~107 kDa protein. Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as CGAS. Acts as an inhibitor of cGAS/STING signaling by catalyzing lactylation of CGAS, preventing the formation of liquid-like droplets in which CGAS is activated. 1. Götz, A. et al. (2011) American journal of human genetics 88, 635-42. PMID: 21549344 2. Li, H. et al. (2024) Nature 634, 1229-1237. PMID: 39322678 |
| 注意事項 | For research use only |
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