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| カタログ番号 | HW501012 |
|---|---|
| 説明 |
Recombinant Human ABCC1 Protein, N-His (HW501012) expressed in E. coli, spanning Glu848-Met967. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P33527 |
| タンパク質長 | Glu848-Met967 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 15.61 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | ABCC1, ATP-binding cassette sub-family C member 1, EC:7.6.2.2, EC:7.6.2.3, Glutathione-S-conjugate-translocating ATPase ABCC1, LTC4 transporter, Leukotriene C(4) transporter, MRP, MRP1, Multidrug resistance-associated protein 1 |
| 背景 | Multidrug resistance-associated protein 1 is a ~171 kDa protein. Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. 1. Sjölinder, M. et al. (1999) Journal of lipid research 40, 439-46. PMID: 10064732 2. Robbiani, DF. et al. (2000) Cell 103, 757-68. PMID: 11114332 3. Conseil, G. et al. (2006) The Journal of biological chemistry 281, 43-50. PMID: 16230346 4. Leier, I. et al. (1994) The Journal of biological chemistry 269, 27807-10. PMID: 7961706 5. Stride, BD. et al. (1997) Molecular pharmacology 52, 344-53. PMID: 9281595 |
| 注意事項 | For research use only |
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