Human ACKR3 Recombinant Protein (N-GST & C-His) (HB259032)

Name: Human ACKR3 Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HB259032
Price: 211 USD
Availability: InStock

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100ug
1mg

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Numéro de catalogue	HB259032
Description	Recombinant Human ACKR3 Protein, N-GST & C-His (HB259032) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	P25106
Longueur de protéine	Asp2-Ser41
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	ACKR3, Atypical chemokine receptor 3, C-X-C chemokine receptor type 7, CMKOR1, CXC-R7, CXCR-7, CXCR7, Chemokine orphan receptor 1, G-protein coupled receptor 159, G-protein coupled receptor RDC1 homolog, GPR159, RDC-1, RDC1
Contexte	Atypical chemokine receptor 3 is a ~41 kDa protein. Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. 1. Balabanian, K. et al. (2005) The Journal of biological chemistry 280, 35760-6. PMID: 16107333 2. Kalatskaya, I. et al. (2009) Molecular pharmacology 75, 1240-7. PMID: 19255243 3. Levoye, A. et al. (2009) Blood 113, 6085-93. PMID: 19380869 4. Naumann, U. et al. (2010) PloS one 5, e9175. PMID: 20161793 5. Ray, P. et al. (2012) The international journal of biochemistry & cell biology 44, 669-78. PMID: 22300987 6. Burns, JM. et al. (2006) The Journal of experimental medicine 203, 2201-13. PMID: 16940167 7. Hartmann, TN. et al. (2008) Journal of leukocyte biology 84, 1130-40. PMID: 18653785 8. Rajagopal, S. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 628-32. PMID: 20018651
Note	For research use only