Human ACKR3 Recombinant Protein (N-GST & C-His) (HB259032)

Name: Human ACKR3 Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HB259032
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HB259032
説明	Recombinant Human ACKR3 Protein, N-GST & C-His (HB259032) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
発現システム	E. coli
アクセッション番号	P25106
タンパク質長	Asp2-Ser41
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Homo sapiens (Human)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	ACKR3, Atypical chemokine receptor 3, C-X-C chemokine receptor type 7, CMKOR1, CXC-R7, CXCR-7, CXCR7, Chemokine orphan receptor 1, G-protein coupled receptor 159, G-protein coupled receptor RDC1 homolog, GPR159, RDC-1, RDC1
背景	Atypical chemokine receptor 3 is a ~41 kDa protein. Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. 1. Balabanian, K. et al. (2005) The Journal of biological chemistry 280, 35760-6. PMID: 16107333 2. Kalatskaya, I. et al. (2009) Molecular pharmacology 75, 1240-7. PMID: 19255243 3. Levoye, A. et al. (2009) Blood 113, 6085-93. PMID: 19380869 4. Naumann, U. et al. (2010) PloS one 5, e9175. PMID: 20161793 5. Ray, P. et al. (2012) The international journal of biochemistry & cell biology 44, 669-78. PMID: 22300987 6. Burns, JM. et al. (2006) The Journal of experimental medicine 203, 2201-13. PMID: 16940167 7. Hartmann, TN. et al. (2008) Journal of leukocyte biology 84, 1130-40. PMID: 18653785 8. Rajagopal, S. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 628-32. PMID: 20018651
注意事項	For research use only