Human ACOD1 Recombinant Protein (N-His) (HC834012)

Name: Human ACOD1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC834012
Price: 211 USD
Availability: InStock

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Número de catálogo	HC834012
Descripción	Recombinant Human ACOD1 Protein, N-His (HC834012) expressed in E. coli, spanning Met1-Ser481. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	A6NK06
Longitud de proteína	Met1-Ser481
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	54.65 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	ACOD1, Aconitate decarboxylase, Aconitate decarboxylase 1, CAD, Cis-aconitate decarboxylase, Cis-aconitic acid decarboxylase, EC:4.1.1.6, IRG1, Immune-responsive gene 1 protein
Fondo	Cis-aconitate decarboxylase is a ~52 kDa protein. Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation. 1. Li, Y. et al. (2013) The Journal of biological chemistry 288, 16225-16234. PMID: 23609450 2. Michelucci, A. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 7820-5. PMID: 23610393 3. Chen, F. et al. (2019) Proceedings of the National Academy of Sciences of the United States of America 116, 20644-20654. PMID: 31548418 4. Zhang, Z. et al. (2022) Molecular cell 82, 2844-2857.e10. PMID: 35662396
Nota	For research use only

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Datasheet

Human ACOD1 Recombinant Protein (N-His).pdf

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