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| カタログ番号 | HC834012 |
|---|---|
| 説明 |
Recombinant Human ACOD1 Protein, N-His (HC834012) expressed in E. coli, spanning Met1-Ser481. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | A6NK06 |
| タンパク質長 | Met1-Ser481 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 54.65 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | ACOD1, Aconitate decarboxylase, Aconitate decarboxylase 1, CAD, Cis-aconitate decarboxylase, Cis-aconitic acid decarboxylase, EC:4.1.1.6, IRG1, Immune-responsive gene 1 protein |
| 背景 | Cis-aconitate decarboxylase is a ~52 kDa protein. Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation. 1. Li, Y. et al. (2013) The Journal of biological chemistry 288, 16225-16234. PMID: 23609450 2. Michelucci, A. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 7820-5. PMID: 23610393 3. Chen, F. et al. (2019) Proceedings of the National Academy of Sciences of the United States of America 116, 20644-20654. PMID: 31548418 4. Zhang, Z. et al. (2022) Molecular cell 82, 2844-2857.e10. PMID: 35662396 |
| 注意事項 | For research use only |
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