Human ACOD1 Recombinant Protein (N-His) (HC834012)

Name: Human ACOD1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC834012
Price: 211 USD
Availability: InStock

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Каталожный номер	HC834012
Описание	Recombinant Human ACOD1 Protein, N-His (HC834012) expressed in E. coli, spanning Met1-Ser481. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	A6NK06
Длина белка	Met1-Ser481
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	54.65 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	ACOD1, Aconitate decarboxylase, Aconitate decarboxylase 1, CAD, Cis-aconitate decarboxylase, Cis-aconitic acid decarboxylase, EC:4.1.1.6, IRG1, Immune-responsive gene 1 protein
Фон	Cis-aconitate decarboxylase is a ~52 kDa protein. Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation. 1. Li, Y. et al. (2013) The Journal of biological chemistry 288, 16225-16234. PMID: 23609450 2. Michelucci, A. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 7820-5. PMID: 23610393 3. Chen, F. et al. (2019) Proceedings of the National Academy of Sciences of the United States of America 116, 20644-20654. PMID: 31548418 4. Zhang, Z. et al. (2022) Molecular cell 82, 2844-2857.e10. PMID: 35662396
Примечание	For research use only

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Human ACOD1 Recombinant Protein (N-His).pdf

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