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| カタログ番号 | HA966022 |
|---|---|
| 説明 |
Recombinant Human ADGRG3 Protein, N-His (HA966022) expressed in E. coli. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q86Y34 |
| タンパク質長 | 2*(Gly396-Thr434) |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 13.03 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | ADGRG3, ADGRG3 C-terminal fragment, ADGRG3 N-terminal fragment, Adhesion G protein-coupled receptor G3, Adhesion G-protein coupled receptor G3, C-terminal fragment, Adhesion G-protein coupled receptor G3, N-terminal fragment, G-protein coupled receptor 97, GPR97, PGR26 |
| 背景 | Adhesion G protein-coupled receptor G3 is a ~60 kDa protein. Adhesion G-protein coupled receptor (aGPCR) for glucocorticoid hormones such as cortisol, cortisone and 11-deoxycortisol. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG3/GPR97 is coupled to G(o)/GNAO1 G proteins and mediates signaling by inhibiting adenylate cyclase activity. May also signal through G-alpha(q)-proteins; additional evidence are however required to confirm this result in vivo. Plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity. 1. Ping, YQ. et al. (2021) Nature 589, 620-626. PMID: 33408414 2. Gupte, J. et al. (2012) FEBS letters 586, 1214-9. PMID: 22575658 3. Hsiao, CC. et al. (2018) Frontiers in immunology 9, 2830. PMID: 30559745 4. Chu, TY. et al. (2022) Nature communications 13, 6385. PMID: 36302784 5. Valtcheva, N. et al. (2013) The Journal of biological chemistry 288, 35736-48. PMID: 24178298 |
| 注意事項 | For research use only |
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