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| カタログ番号 | HC753012 |
|---|---|
| 説明 |
Recombinant Human ADRA1B Protein, N-His-SUMO (HC753012) expressed in E. coli, spanning Arg225-Thr295. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P35368 |
| タンパク質長 | Arg225-Thr295 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 20.42 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | ADRA1B, Alpha-1B adrenergic receptor, Alpha-1B adrenoceptor, Alpha-1B adrenoreceptor |
| 背景 | Alpha-1B adrenergic receptor is a ~56 kDa protein. Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1B binds the catecholamine ligands norepinephrine and epinephrine. Can also couple to G(14) and G(16) proteins. Nuclear ADRA1B forms heterooligomers with ADRA1A to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. 1. Schwinn, DA. et al. (1995) The Journal of pharmacology and experimental therapeutics 272, 134-42. PMID: 7815325 2. Forray, C. et al. (1994) Molecular pharmacology 45, 703-8. PMID: 8183249 3. Wright, CD. et al. (2008) Circulation research 103, 992-1000. PMID: 18802028 4. Wright, CD. et al. (2012) Cellular signalling 24, 794-802. PMID: 22120526 5. Ogata, T. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 3811-6. PMID: 24567387 |
| 注意事項 | For research use only |
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