Human ADRA2A Recombinant Protein (N-His) (HY201012)

Name: Human ADRA2A Recombinant Protein (N-His)
Brand: abinScience
SKU: HY201012
Price: 211 USD
Availability: InStock

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Número de catálogo	HY201012
Descripción	Recombinant Human ADRA2A Protein, N-His (HY201012) expressed in E. coli, spanning Arg233-Phe389. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	P08913
Longitud de proteína	Arg233-Phe389
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	18.73 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	ADRA2A, ADRA2R, ADRAR, Alpha-2 adrenergic receptor subtype C10, Alpha-2A adrenergic receptor, Alpha-2A adrenoceptor, Alpha-2A adrenoreceptor, Alpha-2AAR
Fondo	Alpha-2A adrenergic receptor is a ~50 kDa protein. Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release. ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity. The rank order of potency for agonists of ADRA2A is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. 1. Guyer, CA. et al. (1990) The Journal of biological chemistry 265, 17307-17. PMID: 2170371 2. Li, C. et al. (2012) The Journal of biological chemistry 287, 42784-94. PMID: 23105096 3. Fraser, CM. et al. (1989) The Journal of biological chemistry 264, 11754-61. PMID: 2568356 4. Xu, J. et al. (2022) Science advances 8, eabj5347. PMID: 35245122 5. Garg, A. et al. (2016) JCI insight 1. PMID: 27376152
Nota	For research use only

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Datasheet

Human ADRA2A Recombinant Protein (N-His).pdf

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