Human ADRA2A Recombinant Protein (N-His) (HY201012)

Name: Human ADRA2A Recombinant Protein (N-His)
Brand: abinScience
SKU: HY201012
Price: 211 USD
Availability: InStock

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1mg

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Каталожный номер	HY201012
Описание	Recombinant Human ADRA2A Protein, N-His (HY201012) expressed in E. coli, spanning Arg233-Phe389. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	P08913
Длина белка	Arg233-Phe389
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	18.73 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	ADRA2A, ADRA2R, ADRAR, Alpha-2 adrenergic receptor subtype C10, Alpha-2A adrenergic receptor, Alpha-2A adrenoceptor, Alpha-2A adrenoreceptor, Alpha-2AAR
Фон	Alpha-2A adrenergic receptor is a ~50 kDa protein. Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release. ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity. The rank order of potency for agonists of ADRA2A is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. 1. Guyer, CA. et al. (1990) The Journal of biological chemistry 265, 17307-17. PMID: 2170371 2. Li, C. et al. (2012) The Journal of biological chemistry 287, 42784-94. PMID: 23105096 3. Fraser, CM. et al. (1989) The Journal of biological chemistry 264, 11754-61. PMID: 2568356 4. Xu, J. et al. (2022) Science advances 8, eabj5347. PMID: 35245122 5. Garg, A. et al. (2016) JCI insight 1. PMID: 27376152
Примечание	For research use only

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Human ADRA2A Recombinant Protein (N-His).pdf

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Formula

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