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| カタログ番号 | HC824012 |
|---|---|
| 説明 |
Recombinant Human ADRA2B Protein, N-His (HC824012) expressed in E. coli, spanning Arg194-Arg368. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P18089 |
| タンパク質長 | Arg194-Arg368 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 20.88 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | ADRA2B, ADRA2L1, ADRA2RL1, Alpha-2 adrenergic receptor subtype C2, Alpha-2B adrenergic receptor, Alpha-2B adrenoceptor, Alpha-2B adrenoreceptor, Alpha-2BAR |
| 背景 | Alpha-2B adrenergic receptor is a ~49 kDa protein. Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release. The rank order of potency for agonists of ADRA2B is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. 1. Small, KM. et al. (2001) The Journal of biological chemistry 276, 4917-22. PMID: 11056163 2. Lomasney, JW. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 5094-8. PMID: 2164221 3. Weinshank, RL. et al. (1990) Molecular pharmacology 38, 681-8. PMID: 2172775 4. Li, C. et al. (2012) The Journal of biological chemistry 287, 42784-94. PMID: 23105096 5. Zhang, M. et al. (2016) Molecular and cellular biology 36, 1152-63. PMID: 26811329 |
| 注意事項 | For research use only |
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