Human MIS/AMH Recombinant Protein (N-His) (HY076012)

Name: Human MIS/AMH Recombinant Protein (N-His)
Brand: abinScience
SKU: HY076012
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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Каталожный номер	HY076012
Описание	Recombinant Human AMH Protein, N-His (HY076012) expressed in E. coli, spanning Ala453-Arg560. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	P03971
Длина белка	Ala453-Arg560
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	13.88 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	MIF, AMH, Muellerian-inhibiting factor, Muellerian-inhibiting substance, MIS, Anti-Muellerian hormone
Фон	Anti-Muellerian hormone (AMH) is a ~59 kDa protein. The anti-Muellerian hormone (AMH) plays an important role in several reproductive functions. Anti-Muellerian hormone binds and activates AMHR2, its specific type-II receptor, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A) to regulate target gene expression through downstream SMAD protein signal transduction. Produced and secreted by Sertoli cells of the male fetus, anti-Muellerian hormone induces Muellerian duct regression during male fetal sexual differentiation. In female, it is produced by granulosa cells of the preantral and small antral follicles and acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. Also plays a role in Leydig cell differentiation and function. 1. Weenen, C. et al. (2004) Molecular human reproduction 10, 77-83. PMID: 14742691 2. Hart, KN. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34155118 3. Cate, RL. et al. (1986) Cell 45, 685-98. PMID: 3754790 4. Wilson, CA. et al. (1993) Molecular endocrinology (Baltimore, Md.) 7, 247-57. PMID: 8469238 5. di Clemente, N. et al. (2010) Molecular endocrinology (Baltimore, Md.) 24, 2193-206. PMID: 20861221
Примечание	For research use only.