Human Angiopoietin-2 Recombinant Protein (C-His) (HT073041)

Name: Human Angiopoietin-2 Recombinant Protein (C-His)
Brand: abinScience
SKU: HT073041
Price: 298 USD
Availability: InStock

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50ug
100ug
1mg

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HT073041
説明	Recombinant Human ANGPT2 Protein, C-His (HT073041) expressed in Mammalian Cells, spanning Met1-Phe496. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
発現システム	Mammalian cells
アクセッション番号	O15123
タンパク質長	Met1-Phe496
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Homo sapiens (Human)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
予測分子量	57.88 kDa
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	ANG-2, ANGPT2, Angiopoietin-2
背景	Angiopoietin-2 is a ~56 kDa protein. Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis. 1. Lee, HJ. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1200-8. PMID: 15284220 2. Yacyshyn, OK. et al. (2009) Angiogenesis 12, 25-33. PMID: 19116766 3. Yuan, HT. et al. (2009) Molecular and cellular biology 29, 2011-22. PMID: 19223473 4. Maisonpierre, PC. et al. (1997) Science (New York, N.Y.) 277, 55-60. PMID: 9204896 5. Leppänen, VM. et al. (2020) Science translational medicine 12. PMID: 32908006
注意事項	For research use only

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Bioactivity

Detected by SAA1255 (Catalog No: HT073013) in indirect ELISA.
Bioactivity

Detected by Zifibancimig (Catalog No: HT073086) in indirect ELISA.
Bioactivity

Immobilized HT073041 Human ANGPT2 Recombinant Protein (C-His) at 2 μg/mL(100 μL/well) can bind HX902021 Human CD202b/TEK Recombinant Protein (C-Fc), the EC 50 is 16 μg/mL.