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| カタログ番号 | HC860012 |
|---|---|
| 説明 |
Recombinant Human APBB1 Protein, N-His (HC860012) expressed in E. coli, spanning Asn362-Cys672. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | O00213 |
| タンパク質長 | Asn362-Cys672 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 36.65 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | APBB1, Amyloid beta precursor protein binding family B member 1, Amyloid-beta A4 precursor protein-binding family B member 1, FE65, Protein Fe65, RIR |
| 背景 | Amyloid beta precursor protein binding family B member 1 is a ~77 kDa protein. Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). 1. Perkinton, MS. et al. (2004) The Journal of biological chemistry 279, 22084-91. PMID: 15031292 2. Nakaya, T. et al. (2008) The Journal of biological chemistry 283, 19119-31. PMID: 18468999 3. Lau, KF. et al. (2008) The Journal of biological chemistry 283, 34728-37. PMID: 18922798 4. Matz, A. et al. (2015) Cell death and differentiation 22, 626-42. PMID: 25342469 5. Probst, S. et al. (2021) Biological chemistry 402, 481-499. PMID: 33938178 6. Cook, PJ. et al. (2009) Nature 458, 591-6. PMID: 19234442 7. Kajiwara, Y. et al. (2009) PloS one 4, e5071. PMID: 19343227 8. Chau, DD. et al. (2022) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 36, e22594. PMID: 36250347 |
| 注意事項 | For research use only |
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