Human APLN/Apelin Recombinant Protein (N-His) (HV404022)

Name: Human APLN/Apelin Recombinant Protein (N-His)
Brand: abinScience
SKU: HV404022
Price: 211 USD
Availability: InStock

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Vista general

Número de catálogo	HV404022
Descripción	Recombinant Human APLN Protein, N-His (HV404022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q9ULZ1
Longitud de proteína	Met1-Phe77
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	12.21 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	APEL, APJ endogenous ligand, APLN, Apelin, Apelin-13, Apelin-28, Apelin-31, Apelin-36
Fondo	Apelin is a ~8 kDa protein. Peptide hormone that functions as endogenous ligand for the G-protein-coupled apelin receptor (APLNR/APJ), that plays a role in cadiovascular homeostasis. Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR. Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs. On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor. Apelin blunts cardiac hypertrophic induction from APLNR on response to pathological stimuli, but also induces myocardial hypertrophy under normal conditions. 1. Habata, Y. et al. (1999) Biochimica et biophysica acta 1452, 25-35. PMID: 10525157 2. Scimia, MC. et al. (2012) Nature 488, 394-8. PMID: 22810587 3. Yue, Y. et al. (2022) Nature structural & molecular biology 29, 688-697. PMID: 35817871 4. Wang, WW. et al. (2024) Cell 187, 1460-1475.e20. PMID: 38428423
Nota	For research use only

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Referencias

Datasheet

Human APLN/Apelin Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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