Human ARNT/HIF1-beta Recombinant Protein (N-His) (HB629032)

Name: Human ARNT/HIF1-beta Recombinant Protein (N-His)
Brand: abinScience
SKU: HB629032
Price: 211 USD
Availability: InStock

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Каталожный номер	HB629032
Описание	Recombinant Human ARNT/HIF1-beta Protein, N-His (HB629032) expressed in E. coli, spanning Leu159-Val464. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	P27540
Длина белка	Leu159-Val464
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	36.77 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	ARNT, ARNT protein, Aryl hydrocarbon receptor nuclear translocator, BHLHE2, Class E basic helix-loop-helix protein 2, Dioxin receptor, nuclear translocator, HIF-1-beta, HIF1-beta, Hypoxia-inducible factor 1-beta, bHLHe2
Фон	Aryl hydrocarbon receptor nuclear translocator is a ~86 kDa protein. Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. 1. Haidar, R. et al. (2021) Scientific reports 11, 18194. PMID: 34521881 2. Seok, SH. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 5431-5436. PMID: 28396409
Примечание	For research use only

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Human ARNT/HIF1-beta Recombinant Protein (N-His).pdf

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