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| カタログ番号 | HD029012 |
|---|---|
| 説明 |
Recombinant Human ASIP Protein, N-His-KSI (HD029012) expressed in E. coli, spanning His23-Cys132. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P42127 |
| タンパク質長 | His23-Cys132 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 27.81 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | AGTI, AGTIL, ASIP, ASP, Agouti switch protein, Agouti-signaling protein |
| 背景 | Agouti-signaling protein is a ~14 kDa protein. Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptor MC1R, thereby playing a role in the regulation of melanogenesis. Binding to MC1R prevents alpha-MSH-induced signaling and inhibits cAMP production, resulting in down-regulation of eumelanogenesis (brown/black pigment) and increased pheomelanin (yellow/red pigment) synthesis. In higher primates, Agouti may affect the quality of hair pigmentation rather than the pattern of pigment deposition. May also play a role in neuroendocrine aspects of melanocortin action. 1. Kempf, E. et al. (2022) Nature metabolism 4, 1697-1712. PMID: 36536132 2. Kanetsky, PA. et al. (2002) American journal of human genetics 70, 770-5. PMID: 11833005 |
| 注意事項 | For research use only |
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