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| カタログ番号 | HD739012 |
|---|---|
| 説明 |
Recombinant Human ATG9A Protein, N-His (HD739012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q7Z3C6 |
| タンパク質長 | Cys155-Pro371 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | APG9-like 1, APG9L1, ATG9A, Autophagy-related protein 9A, mATG9 |
| 背景 | Autophagy-related protein 9A is a ~94 kDa protein. Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1. In addition to autophagy, also plays a role in necrotic cell death. 1. Orsi, A. et al. (2012) Molecular biology of the cell 23, 1860-73. PMID: 22456507 2. Karanasios, E. et al. (2016) Nature communications 7, 12420. PMID: 27510922 3. Søreng, K. et al. (2018) EMBO reports 19. PMID: 29437695 4. Antón, Z. et al. (2020) Journal of cell science 133. PMID: 32513819 5. Guardia, CM. et al. (2020) Cell reports 31, 107837. PMID: 32610138 6. Maeda, S. et al. (2020) Nature structural & molecular biology 27, 1194-1201. PMID: 33106659 7. Ravussin, A. et al. (2021) Journal of cell science 134. PMID: 33468622 8. Ghanbarpour, A. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 33850023 9. Young, AR. et al. (2006) Journal of cell science 119, 3888-900. PMID: 16940348 10. Judith, D. et al. (2019) The Journal of cell biology 218, 1634-1652. PMID: 30917996 |
| 注意事項 | For research use only |
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