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| カタログ番号 | HD825012 |
|---|---|
| 説明 |
Recombinant Human ATL1 Protein, N-His (HD825012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q8WXF7 |
| タンパク質長 | Gly33-Gly338 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | ATL-1, ATL1, Atlastin-1, Brain-specific GTP-binding protein, EC:3.6.5.-, GBP-3, GBP3, GTP-binding protein 3, Guanine nucleotide-binding protein 3, SPG3, SPG3A, Spastic paraplegia 3 protein A, hGBP3 |
| 背景 | Atlastin-1 is a ~63 kDa protein. Atlastin-1 (ATL1) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect. Two atlastin-1 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). 1. Zhu, PP. et al. (2003) The Journal of biological chemistry 278, 49063-71. PMID: 14506257 2. Rismanchi, N. et al. (2008) Human molecular genetics 17, 1591-604. PMID: 18270207 3. Hu, J. et al. (2009) Cell 138, 549-61. PMID: 19665976 4. Wang, S. et al. (2016) eLife 5. PMID: 27619977 5. Crosby, D. et al. (2022) The Journal of cell biology 221. PMID: 34817557 6. Shi, L. et al. (2024) Nature communications 15, 2488. PMID: 38509071 7. Byrnes, LJ. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2216-21. PMID: 21220294 8. Bian, X. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 3976-81. PMID: 21368113 9. Byrnes, LJ. et al. (2013) The EMBO journal 32, 369-84. PMID: 23334294 |
| 注意事項 | For research use only |
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