Human ATP2C2 Recombinant Protein (N-His) (HF519022)

Name: Human ATP2C2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HF519022
Price: 211 USD
Availability: InStock

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100ug
1mg

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Каталожный номер	HF519022
Описание	Recombinant Human ATP2C2 Protein, N-His (HF519022) expressed in E. coli, spanning Glu388-Asp576. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	O75185
Длина белка	Glu388-Asp576
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	22.92 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	ATP2C2, ATPase 2C2, Ca(2+)/Mn(2+)-ATPase 2C2, Calcium-transporting ATPase type 2C member 2, EC:7.2.2.10, KIAA0703, SPCA2, Secretory pathway Ca(2+)-transporting ATPase type 2
Фон	Calcium-transporting ATPase type 2C member 2 is a ~103 kDa protein. ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. 1. Xiang, M. et al. (2005) The Journal of biological chemistry 280, 11608-14. PMID: 15677451 2. Vanoevelen, J. et al. (2005) The Journal of biological chemistry 280, 22800-8. PMID: 15831496 3. Dode, L. et al. (2006) The Journal of biological chemistry 281, 3182-9. PMID: 16332677 4. Chen, J. et al. (2019) The Journal of biological chemistry 294, 7878-7891. PMID: 30923126 5. Feng, M. et al. (2010) Cell 143, 84-98. PMID: 20887894 6. Cross, BM. et al. (2013) PloS one 8, e67348. PMID: 23840669
Примечание	For research use only

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Human ATP2C2 Recombinant Protein (N-His).pdf

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