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| カタログ番号 | HC936012 |
|---|---|
| 説明 |
Recombinant Human ATP8B1 Protein, N-His (HC936012) expressed in E. coli, spanning Arg412-Lys949. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | O43520 |
| タンパク質長 | Arg412-Lys949 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 63.88 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | ATP8B1, ATPIC, ATPase class I type 8B member 1, EC:7.6.2.1, FIC1, Familial intrahepatic cholestasis type 1, P4-ATPase flippase complex alpha subunit ATP8B1, PFIC, Phospholipid-transporting ATPase IC |
| 背景 | Phospholipid-transporting ATPase IC is a ~143 kDa protein. Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane. May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane. Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2. 1. Paulusma, CC. et al. (2008) Hepatology (Baltimore, Md.) 47, 268-78. PMID: 17948906 2. Takatsu, H. et al. (2014) The Journal of biological chemistry 289, 33543-56. PMID: 25315773 3. Verhulst, PM. et al. (2010) Hepatology (Baltimore, Md.) 51, 2049-60. PMID: 20512993 4. van der Mark, VA. et al. (2014) Biochimica et biophysica acta 1842, 2378-86. PMID: 25239307 5. van der Mark, VA. et al. (2016) Biochimica et biophysica acta 1863, 2280-8. PMID: 27301931 6. Muñoz-Martínez, F. et al. (2010) Biochemical pharmacology 80, 793-800. PMID: 20510206 |
| 注意事項 | For research use only |
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