Human ATP8B1 Recombinant Protein (N-His) (HC936012)

Name: Human ATP8B1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC936012
Price: 211 USD
Availability: InStock

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100ug
1mg

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Каталожный номер	HC936012
Описание	Recombinant Human ATP8B1 Protein, N-His (HC936012) expressed in E. coli, spanning Arg412-Lys949. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	O43520
Длина белка	Arg412-Lys949
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	63.88 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	ATP8B1, ATPIC, ATPase class I type 8B member 1, EC:7.6.2.1, FIC1, Familial intrahepatic cholestasis type 1, P4-ATPase flippase complex alpha subunit ATP8B1, PFIC, Phospholipid-transporting ATPase IC
Фон	Phospholipid-transporting ATPase IC is a ~143 kDa protein. Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane. May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane. Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2. 1. Paulusma, CC. et al. (2008) Hepatology (Baltimore, Md.) 47, 268-78. PMID: 17948906 2. Takatsu, H. et al. (2014) The Journal of biological chemistry 289, 33543-56. PMID: 25315773 3. Verhulst, PM. et al. (2010) Hepatology (Baltimore, Md.) 51, 2049-60. PMID: 20512993 4. van der Mark, VA. et al. (2014) Biochimica et biophysica acta 1842, 2378-86. PMID: 25239307 5. van der Mark, VA. et al. (2016) Biochimica et biophysica acta 1863, 2280-8. PMID: 27301931 6. Muñoz-Martínez, F. et al. (2010) Biochemical pharmacology 80, 793-800. PMID: 20510206
Примечание	For research use only

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Human ATP8B1 Recombinant Protein (N-His).pdf

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