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| カタログ番号 | HD348012 |
|---|---|
| 説明 |
Recombinant Human BRAT1 Protein, N-His (HD348012) expressed in E. coli, spanning Met1-Gly291. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q6PJG6 |
| タンパク質長 | Met1-Gly291 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 33.38 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | BAAT1, BRAT1, BRCA1-associated ATM activator 1, BRCA1-associated protein required for ATM activation protein 1, C7orf27, Integrator complex assembly factor BRAT1 |
| 背景 | Integrator complex assembly factor BRAT1 is a ~88 kDa protein. Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex. Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex. Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer. In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. 1. Sabath, K. et al. (2024) Molecular cell 84, 2882-2899.e10. PMID: 39032489 2. Lin, MH. et al. (2024) Molecular cell 84, 2900-2917.e10. PMID: 39032490 3. Aglipay, JA. et al. (2006) The Journal of biological chemistry 281, 9710-8. PMID: 16452482 4. So, EY. et al. (2011) Experimental and therapeutic medicine 2, 443-447. PMID: 22977523 5. So, EY. et al. (2014) BMC cancer 14, 548. PMID: 25070371 6. So, EY. et al. (2013) Journal of cancer biology & research 1. PMID: 25657994 |
| 注意事項 | For research use only |
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