Human BRIP1 Recombinant Protein (N-His) (HD382012)

Name: Human BRIP1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD382012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HD382012
Description	Recombinant Human BRIP1 Protein, N-His (HD382012) expressed in E. coli, spanning Ile243-Asn595. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q9BX63
Longueur de protéine	Ile243-Asn595
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	43.05 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	BACH1, BRCA1-associated C-terminal helicase 1, BRCA1-interacting protein 1, BRCA1-interacting protein C-terminal helicase 1, BRIP1, DNA 5'-3' helicase FANCJ, EC:5.6.2.3, FANCJ, Fanconi anemia group J protein
Contexte	Fanconi anemia group J protein is a ~140 kDa protein. DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease. Can unwind RNA:DNA substrates. 1. Cantor, SB. et al. (2001) Cell 105, 149-60. PMID: 11301010 2. Cantor, S. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 2357-62. PMID: 14983014 3. Bridge, WL. et al. (2005) Nature genetics 37, 953-7. PMID: 16116421 4. Litman, R. et al. (2005) Cancer cell 8, 255-65. PMID: 16153896 5. Gupta, R. et al. (2007) Blood 110, 2390-8. PMID: 17596542 6. Yaneva, D. et al. (2023) Molecular cell 83, 43-56.e10. PMID: 36608669
Note	For research use only

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Human BRIP1 Recombinant Protein (N-His).pdf

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