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| カタログ番号 | HD382012 |
|---|---|
| 説明 |
Recombinant Human BRIP1 Protein, N-His (HD382012) expressed in E. coli, spanning Ile243-Asn595. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q9BX63 |
| タンパク質長 | Ile243-Asn595 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 43.05 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | BACH1, BRCA1-associated C-terminal helicase 1, BRCA1-interacting protein 1, BRCA1-interacting protein C-terminal helicase 1, BRIP1, DNA 5'-3' helicase FANCJ, EC:5.6.2.3, FANCJ, Fanconi anemia group J protein |
| 背景 | Fanconi anemia group J protein is a ~140 kDa protein. DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease. Can unwind RNA:DNA substrates. 1. Cantor, SB. et al. (2001) Cell 105, 149-60. PMID: 11301010 2. Cantor, S. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 2357-62. PMID: 14983014 3. Bridge, WL. et al. (2005) Nature genetics 37, 953-7. PMID: 16116421 4. Litman, R. et al. (2005) Cancer cell 8, 255-65. PMID: 16153896 5. Gupta, R. et al. (2007) Blood 110, 2390-8. PMID: 17596542 6. Yaneva, D. et al. (2023) Molecular cell 83, 43-56.e10. PMID: 36608669 |
| 注意事項 | For research use only |
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