Human BTLA/CD272 Recombinant Protein (C-Fc) (HV375021)

Name: Human BTLA/CD272 Recombinant Protein (C-Fc)
Brand: abinScience
SKU: HV375021
Price: 298 USD
Availability: InStock

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50ug
100ug
1mg

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер	HV375021
Описание	Recombinant Human BTLA Protein, C-Fc (HV375021) expressed in Mammalian Cells, spanning Met1-Ser150. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	Mammalian cells
Номер доступа	Q7Z6A9
Длина белка	Met1-Ser150
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	43.65 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein, BTLA, CD272
Фон	B- and T-lymphocyte attenuator is a ~32 kDa protein. Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. 1. Watanabe, N. et al. (2003) Nature immunology 4, 670-9. PMID: 12796776 2. Gavrieli, M. et al. (2003) Biochemical and biophysical research communications 312, 1236-43. PMID: 14652006 3. Sedy, JR. et al. (2005) Nature immunology 6, 90-8. PMID: 15568026 4. Cai, G. et al. (2008) Nature immunology 9, 176-85. PMID: 18193050 5. Cheung, TC. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 7286-96. PMID: 19915044
Примечание	For research use only

Изображения

Bioactivity

Immobilized HV375021 Human BTLA Recombinant Protein (C-Fc) at 2 μg/mL(100 μL/well) can bind HV480011 Human CD270/TNFRSF14 Recombinant Protein (C-His), the EC 50 is 15.2 μg/mL.
Bioactivity

Immobilized HV375021 Human BTLA Recombinant Protein (C-Fc) at 2 μg/mL(100 μL/well) can bind MV480011 Mouse CD270/TNFRSF14 Recombinant Protein (C-Fc), the EC 50 is 251 ng/mL.