中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HD735012 |
|---|---|
| 説明 |
Recombinant Human BTRC Protein, N-His (HD735012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q9Y297 |
| タンパク質長 | His291-Asp581 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | BTRC, BTRCP, E3RSIkappaB, Epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, F-box/WD repeat-containing protein 1A, FBW1A, FBXW1A, pIkappaBalpha-E3 receptor subunit |
| 背景 | F-box/WD repeat-containing protein 1A is a ~68 kDa protein. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. 1. Suzuki, H. et al. (1999) Biochemical and biophysical research communications 256, 127-32. PMID: 10066435 2. Shirane, M. et al. (1999) The Journal of biological chemistry 274, 28169-74. PMID: 10497169 3. Suzuki, H. et al. (2000) The Journal of biological chemistry 275, 2877-84. PMID: 10644755 4. Orian, A. et al. (2000) The EMBO journal 19, 2580-91. PMID: 10835356 5. Heissmeyer, V. et al. (2001) Molecular and cellular biology 21, 1024-35. PMID: 11158290 6. Lassot, I. et al. (2001) Molecular and cellular biology 21, 2192-202. PMID: 11238952 7. Fukuchi, M. et al. (2001) Molecular biology of the cell 12, 1431-43. PMID: 11359933 8. Fong, A. et al. (2002) The Journal of biological chemistry 277, 22111-4. PMID: 11994270 9. Margottin-Goguet, F. et al. (2003) Developmental cell 4, 813-26. PMID: 12791267 10. Mantovani, F. et al. (2003) The Journal of biological chemistry 278, 42477-86. PMID: 12902344 |
| 注意事項 | For research use only |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
