Human C7 Recombinant Protein (N-His) (HY181032)

Name: Human C7 Recombinant Protein (N-His)
Brand: abinScience
SKU: HY181032
Price: 211 USD
Availability: InStock

Fiche technique Partager le produit Copier les informations

Prix(USD) :

Spécification :

50ug
100ug
1mg

Nombre :

Contactez-nous

Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue	HY181032
Description	Recombinant Human C7 Protein, N-His (HY181032) expressed in E. coli, spanning Glu569-Gln843. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	P10643
Longueur de protéine	Glu569-Gln843
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	32.29 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	C7, Complement component C7
Contexte	Complement component C7 is a ~93 kDa protein. Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C7 serves as a membrane anchor. During MAC assembly, associates with C5b and C6 to form the C5b-7 complex, a key lipophilic precursor of the MAC complex, which associates with the outer leaflet and reduces the energy for membrane bending. 1. Hadders, MA. et al. (2012) Cell reports 1, 200-7. PMID: 22832194 2. Serna, M. et al. (2016) Nature communications 7, 10587. PMID: 26841837 3. Sharp, TH. et al. (2016) Cell reports 15, 1-8. PMID: 27052168 4. Menny, A. et al. (2018) Nature communications 9, 5316. PMID: 30552328 5. DiScipio, RG. et al. (1988) The Journal of biological chemistry 263, 549-60. PMID: 3335508 6. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456 7. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882
Note	For research use only