中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HD272012 |
|---|---|
| 説明 |
Recombinant Human CCDC88A Protein, N-His (HD272012) expressed in E. coli, spanning Met1-Phe223. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q3V6T2 |
| タンパク質長 | Met1-Phe223 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 27.85 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | APE, Akt phosphorylation enhancer, CCDC88A, Coiled-coil domain-containing protein 88A, G alpha-interacting vesicle-associated protein, GIV, GRDN, Girders of actin filament, Girdin, HkRP1, Hook-related protein 1, KIAA1212 |
| 背景 | Girdin is a ~216 kDa protein. Bifunctional modulator of guanine nucleotide-binding proteins (G proteins). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits. Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS. Essential for cell migration. Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration. 1. Garcia-Marcos, M. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 3178-83. PMID: 19211784 2. Gupta, V. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E5721-30. PMID: 27621449 3. Lin, C. et al. (2011) Science signaling 4, ra64. PMID: 21954290 4. López-Sánchez, I. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 5510-5. PMID: 23509302 5. Lin, C. et al. (2014) Molecular biology of the cell 25, 3654-71. PMID: 25187647 6. Enomoto, A. et al. (2005) Developmental cell 9, 389-402. PMID: 16139227 7. Ghosh, P. et al. (2010) Molecular biology of the cell 21, 2338-54. PMID: 20462955 |
| 注意事項 | For research use only |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
