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| カタログ番号 | HC948012 |
|---|---|
| 説明 |
Recombinant Human CCNT1 Protein, N-His (HC948012) expressed in E. coli, spanning Met1-Ser290. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | O60563 |
| タンパク質長 | Met1-Ser290 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 35.52 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CCNT1, CycT1, Cyclin-T, Cyclin-T1 |
| 背景 | Cyclin-T1 is a ~80 kDa protein. Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II. 1. Jang, MK. et al. (2005) Molecular cell 19, 523-34. PMID: 16109376 2. Yang, Z. et al. (2005) Molecular cell 19, 535-45. PMID: 16109377 3. Ghosh, K. et al. (2018) Cell reports 24, 2141-2154.e6. PMID: 30134174 4. Fu, H. et al. (2022) Nature cell biology 24, 513-525. PMID: 35393539 5. Lu, H. et al. (2018) Nature 558, 318-323. PMID: 29849146 |
| 注意事項 | For research use only |
SDS-PAGE for Human CCNT1 Recombinant Protein (N-His)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
