Human CCR8 Recombinant Protein (N-His-KSI) (HW444032)

Name: Human CCR8 Recombinant Protein (N-His-KSI)
Brand: abinScience
SKU: HW444032
Price: 211 USD
Availability: InStock

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1mg

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Numéro de catalogue	HW444032
Description	Recombinant Human CCR8 Protein, N-His-KSI (HW444032) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	P51685
Longueur de protéine	Met1-Lys35&Lys64-Tyr73&Tyr94-Lys107&Asp130-Thr146&Tyr172-Met202&His223-Arg238&His264-Tyr280&Glu305-Leu355
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	C-C CKR-8, C-C chemokine receptor type 8, CC chemokine receptor CHEMR1, CC-CKR-8, CCR-8, CCR8, CDw198, CKR-L1, CKRL1, CMKBR8, CMKBRL2, Chemokine receptor-like 1, GPR-CY6, GPRCY6, TER1
Contexte	C-C chemokine receptor type 8 is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage. 1. Islam, SA. et al. (2013) The Journal of experimental medicine 210, 1889-98. PMID: 23999500 2. Ding, D. et al. (2022) Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 42, 19-28. PMID: 35041514
Note	For research use only